Functional or secondary mitral regurgitation (FMR/SMR) is a heart valve lesion that is diagnosed in nearly 50% of the patients surviving with atrial or ventricular cardiomyopathies.

FMR increases 5-year mortality by 70% in HF patients*, and causes 4X the heart failure hospitalizations*, compared to those patients without FMR. Patients have poor quality of life.

Treating FMR in an effective and timely manner is shown to have significant survival benefit, reduce heart failure hospitalizations and improve the patients quality of life

* Grigioni F et al. Contribution of ischemic mitral regurgitation to congestive heart failure after myocardial infarction. JACC, 2005, 45(2): 260-7.

FMR causes debilitating symptoms that adversely impact the patients quality of life, which often cannot be managed with medical therapy